ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, characterization, and biological activities of oxovanadium(IV) and cadmium(II) complexes with reduced Schiff bases derived from N,Nʹ-o-phenylenebis(salicylideneimine)

Sabrina Belaid, Ouassini Benali-Baïtich, Gilles Bouet, and Anne Landreau

Laboratoire de Physico-Chimie des Matériaux et Catalyse, Faculté des Sciences Exactes, Université de Bejaia, 06000 Bejaia, Algeria

E-mail: gilles.bouet@univ-angers.fr

Abstract: New oxovanadium(IV) and cadmium(II) complexes with reduced Schiff bases derived from N,Nʹ- o-phenylenebis(salicylideneimine) have been synthesized and characterized using infrared and UVvisible spectra, ESR, and thermogravimetry. The complexes were identified as [ML] · (H₂O) species, where deprotonated ligands are coordinated to metal through N₂O₂ donor atoms. Antioxidant activity of the ligands and complexes was evaluated, revealing that the complexes exhibit a higher scavenging activity than the corresponding ligands. The prepared cadmium complexes showed slightly higher activity than the vanadium ones. Antifungal activity was tested against different human fungi including yeasts of the Candida genus (C. albicans and C. glabrata) and an opportunistic mould Aspergillus fumigatus. The oxovanadium complexes exhibited a very low activity toward C. albicans while the cadmium ones showed a significant growth inhibition of all the fungi tested; mainly of A. fumigatus though this mould is poorly susceptible to current antifungal agents like Itraconazole.

Keywords: reduced Schiff bases – cadmium – oxovanadium – antifungal agents – antioxidant activity

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2015-0132

Chemical Papers 69 (10) 1350–1360 (2015)