ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Piroxicam /β-cyclodextrin complex included in cellulose derivatives-based matrix microspheres as new solid dispersion-controlled release formulations

Oum Elkheir Khoukhi, Zineb El Bahri, Kheira Diaf, and Milad Baitiche

^aaLaboratory of Advanced Materials and Physical Chemistry for Environment and Health, Faculty of Exact Sciences,Djillali Liabès University of Sidi Bel Abbès, 22000 Algeria

E-mail: elbahrizineb@yahoo.fr

Abstract: New formulations capable to enhance piroxicam (PRX) water solubility and at the same time to control and adjust its release have been developed. For this purpose, two methods have been used and combined to achieve this goal, namely complexation and microencapsulation by O/W emulsion solvent evaporation. In order to modify the drug release, first, microparticles composed of pure PRX and ethylcellulose (EC) or mixtures of EC and hydroxypropylmethylcellulose (HPMC) were prepared, and then, other micropaticles containing the,β-cyclodextrin/piroxicam (,β-CD/PRX) complex obtained by the solvent evaporation technique and EC or a mixture of EC and HPMC were produced and tested. These formulations were characterized by FT-IR, XRD, optical microscopy, and SEM methods. Drug dissolution tests were carried out in acidic media at pH = 1.2 and 37 °C. Depending on the microparticles composition, their size (dio) ranged between 49 pm and 121 pm and PRXioaded varied from 10.8 % to 27.7 %. The effect of complexation and HPMC polymer on the drug release was investigated; the results demonstrated that the Higuchi’s release constant significantly increased when using the EC/HPMC mixture as a matrix with pure PRX or only EC as a matrix with the ,β-CD/PRX complex. The results are remarkably promising since the combination of these processes provided new SD-CR formulations of piroxicam which enabled simultaneous enhancement and control of its release from the carriers.

Keywords: piroxicam – complex inclusion – microencapsulation – ethylcellulose – β-cyclodextrin – SD- CR formulation

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2016-0014

Chemical Papers 70 (6) 828–839 (2016)