ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Alkyl glycosides as potential anti-Candida albicans growth agents

Tomáš Klunda, Eva Machová, Alžbeta Čížová, Radim Horák, Monika Poláková, and Slavomír Bystrický

Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovakia

E-mail: monika.polakova@savba.sk

Abstract: Candida infections are becoming increasingly prevalent and many clinical isolates are resistant to common azole derivatives treatment. Accordingly, the capacity of a series of 19 alkyl glycosides, mainly mannosides and glucosides but also a cellobioside with aglycone chain-length from C-6 to C-20, to inhibit the growth of laboratory and clinically isolated strains of Candida albicans, was investigated. The study showed that only glycosides with the C-10 and C-12 aglycones were effective growth inhibitors of both types of Candida strains, whose metabolic activity was also significantly reduced as revealed by an XTT assay.

Keywords: susceptibility – synthetic glycosides – Candida albican

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2016-0051

Chemical Papers 70 (9) 1166–1170 (2016)