ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

An efficient synthesis of β-methoxycarbonyl-γ-butyrolactones

Ruirui Li, Zhiqiang Li, Lan Jiang, and Zhengning Li

College of Environmental and Chemical Engineering, Dalian University, Dalian, China

E-mail: jianglan@dlu.edu.cn

Abstract: β-Methoxycarbonyl-γ-butyrolactones bearing a γ-aromatic substituent were prepared via copper-catalyzed reductive aldol addition/lactonization domino reactions of ketones with α,β-unsaturated dicarboxylate esters and a silane under ambient temperature. The reaction has advantage of using readily available reagents, mild conditions and high efficiency.

Keywords: Copper hydride; Domino reaction; γ-Lactone; Synthesis; Catalysis

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-017-0175-y

Chemical Papers 71 (10) 1825–1828 (2017)