ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

Abdelmounaim Safer, Mustapha Rahmouni, François Carreaux, Ludovic Paquin, Olivier Lozach, Laurent Meijer, and Jean Pierre Bazureau

Laboratoire de Synthèse et de Catalyse, Université Ibn Khaldoun, 14000 Tiaret, Algérie

E-mail: jean-pierre.bazureau@univ-rennes1.fr

Abstract: A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM.

Keywords: rhodanine – isatin – Knoevenagel condensation – solvent-free microwave

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-010-0104-9

Chemical Papers 65 (3) 332–337 (2011)