ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, anticancer evaluation and molecular docking studies of bis(indolyl) triazinones, Nortopsentin analogs

Reddymasu Sreenivasulu, Rudavath Durgesh, Surender Singh Jadav, Pombala Sujitha, C. Ganesh Kumar, and Rudraraju Ramesh Raju

Acharya Nagarjuna University, Guntur, India

E-mail: rrraju1@gmail.com

Abstract: A new series of bis indolyl tri keto diazo compounds and 3,5-bis(3′-indolyl) triazinones were designed and synthesized as anticancer agents. Their anticancer activity was screened in vitro towards four different human cancer cell lines like HeLa, MCF-7, MDA-MB-231 and A549 cell lines. Among them, compounds 17a and 17b showed potent cytotoxicity with inhibition (IC₅₀) values of 4.6 and 1.3 µM on Human Cervical cancer cell line, respectively. The in silico simulation studies using ADT 1.5.6 tools revealed unique π–π interactions of indole ring of compound 17b with colchicines active site residue Tyr312 could be a valid reason behind its maximum potency when compared to remaining compounds in responsible of its higher activity.

Keywords: Nortopsentins ; Triazinones ; Diazo tri keto compounds ; Anti-tumor activity ; Colchicine 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-017-0372-8

Chemical Papers 72 (6) 1369–1378 (2018)