ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

A regio- and stereoselective three-component synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidine derivatives under solvent-free conditions

Abbas Rahmati

Department of Chemistry, University of Isfahan, Isfahan, 81746-73441 Iran

E-mail: a.rahmati@sci.ui.ac.ir

Abstract: An efficient one-pot method for regio- and stereoselective synthesis of 5-(trifluoromethyl)-4,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidines under solvent-free and catalyst-free conditions has been developed. The method involves employing a three-component condensation reaction of an aromatic aldehyde and ethyl 4,4,4-trifluoro-3-oxobutanoate or 1,1,1-trifluoropentane-2,4-dione in the presence of 1,2,4-triazol-3-amine at 90°C.

Keywords: fluorinated compounds – 1,2,4-triazol-3-amine – solvent-free – catalyst-free

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-011-0034-1

Chemical Papers 65 (4) 536–541 (2011)