ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Biocatalytic one-pot three-component synthesis of 4H-chromene derivatives in non-aqueous medium

Prabhakar Shrivas and Umesh Pratap

Visvesvaraya National Institute of Technology, Nagpur, India

E-mail: umeshpratap2014@gmail.com

Abstract: The baker’s yeast catalyzed one-pot three-component cyclocondensation of salicylaldehyde, malononitrile or ethyl cyanoacetate, and nitroalkanes for the synthesis of substituted 2-amino-4H-chromene derivatives is presented. The highlights of the protocol is a use of a biodegradable catalyst which is inexpensive, having simple reaction conditions, in other words, at room temperature and neutral pH, good-to-excellent yield, and simple workup procedure.

Keywords: Baker’s yeast ; Chromene ; Knoevenagel condensation ; Michael addition ; Biocatalysis 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-018-00679-5

Chemical Papers 73 (5) 1301–1307 (2019)