ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Efficient synthesis of new 3-amino-4-cyanothiophene derivatives

Salwa E. M. El-Meligie, Nadia A. Khalil, Hala B. El-Nassan, and Ahmed A. M. Ibraheem

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

E-mail: hala_bakr@hotmail.com

Received: 1 October 2019  Accepted: 20 January 2020

Abstract:

An efficient and atom economic modification of a previously reported synthetic pathway to tetrasubstituted thiophenes is described. The previously published synthetic methodology involved a one pot procedure starting with ketene dithioacetal and an appropriate secondary amine, and subsequent reaction with Na₂S and phenacyl bromide. However, the liberated methanethiolate by-product was competed with enethiolate intermediate for phenacyl bromide, which reduced the yield and imposed the necessity to use two molar equivalents of α-haloketone reagent to increase the yield of the target thiophene products. In the present work, the proposed modification consisted in isolation of the intermediate enethiolate derivative, thereby reducing quantity of the α-haloketone to one molar equivalent. Moreover, the reaction conditions were optimized to attain optimum base/solvent combination to improve the yield of the target derivatives. Following our modified procedure, three series of new 3-amino-4-cyanothiophene derivatives were synthesized and isolated in high yields and high purity.

Keywords: Thiophene; 3-Amino-4-cyanothiophene; Ketene dithioacetals; Thiophene-2-carboxamides

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01070-z

Chemical Papers 74 (8) 2491–2500 (2020)