ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)

Venansia Avelia Rosari, Witri Wahyu Lestari, and Maulidan Firdaus

Magister of Chemistry Programme, Universitas Sebelas Maret, Surakarta, Indonesia

E-mail: witri@mipa.uns.ac.id

Received: 8 August 2019  Accepted: 19 February 2020

Abstract:

An aspirin-ligated cisplatin derivative, biasplatin, was prepared from acetylsalicylic anhydride and oxoplatin in DMF. Biasplatin was synthesized from oxoplatin and aspirin anhydride as starting materials by a substitution reaction of hydroxo leaving groups in its axial position. The obtained biasplatin was fully characterized by FTIR, ¹HNMR, ¹³CNMR, and ESI mass spectroscopy. Biasplatin entrapped into MIL-101(Fe) by suspended in DMF and stirring for 72 h at ambient temperature, known as biasplatin@MIL-101(Fe). The slow release of biasplatin and biasplatin@MIL-101(Fe) was conducted in PBS solution pH 7.20, 37 °C as media and measured by UV–Vis spectrophotometer. The release of biasplatin without loaded into MIL-101(Fe) is persistent for 3%, and biasplatin@MIL-101(Fe) is 0.05% over 72 h. A significant slow release of biasplatin@MIL-101(Fe) only 1% compared with time release of biasplatin without loaded into MIL-101(Fe).

Keywords: Cisplatin derivatives; Biasplatin; Aspirin; MIL-101(Fe); Time release

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01114-4

Chemical Papers 74 (8) 2733–2741 (2020)