ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, characterization, and biological activities of some transition metal(II) complexes with the thiosemicarbazone derived from 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one

J. Q. Qu, G. C. Sun, L. F. Wang, and L. Qu

Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, P. R. China

E-mail: jqqu@tju.edu.cn

Received: 6 May 2005  Revised: 29 March 2006  Accepted: 3 April 2006

Abstract: A new 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one thiosemicarbazone (HL) was synthesized derived from 4-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]but-3-en-2-one. Four transition metal(II) complexes of HL have been prepared. Elemental analysis, molar conductivity, IR, UV, ¹H NMR spectra, and TG-DTA have been used to characterize these complexes. The complexes have the general formula ML₂, where M = Zn, Cu, Co, and Ni. The ligand and its complexes have been studied for their possible biological activity including anti-inflammatory, antibacterial, and antitumour activity in vitro.

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-006-0038-4

Chemical Papers 60 (3) 214–219 (2006)