ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

New photoluminescent Zn(II)/Cd(II) coordination polymers for laryngeal carcinoma therapy

Xiao-Ling He, Fu-Hui Huang, Chun-Ming Zhang, Zhen Dong, and Bin-Quan Wang

The First Clinical Medical College of Shanxi Medical University, Taiyuan, China

E-mail: okitoppr71726@163.com

Received: 12 October 2021  Accepted: 27 December 2021

Abstract:

The larynx is an important organ of human speech, and patients with laryngeal cancer may face great pain of losing their functions. For the prevention and therapy of laryngeal carcinoma, two new Zn(II)/Cd(II) coordination polymers, namely [Zn₃(L)₂(4,4′-bipy)]_n·2n(DMF) (1) and [Cd₃(L)₂(bpp₂)_n·2n(H₂O)·2n(DMF) (2) (H₃L = 4,4′,4′′-ticarboxytriphenylamine, 4,4′-bipy = 4,4′-bipyridine, bpp = 1,3-bis(4-pyridyl)propane, DMF = N,N-dimethylformamide), were prepared. The treatment and protection activity of the new compounds against the laryngeal carcinoma was evaluated in this research, and the corresponding mechanism was explored at the same time. Firstly, CCK-8 assay was conducted to measure the inhibitory activity of compounds on the viability of laryngeal carcinoma cells. Additionally, the expression of miR-223-3P in MSC exosomes was also measured by real time RT-PCR assay.

Keywords: Coordination polymer; Solvothermal reaction; Luminescence; Laryngeal carcinoma

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-021-02048-1

Chemical Papers 76 (5) 2875–2882 (2022)