ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

New strategy for the synthesis of 3-ethynyl-2-(thiophen-2-yl)benzo[b]thiophene derivatives

Muheb A. S. Algso and Arif Kivrak

Van Yüzüncü Yil University, Van, Turkey

E-mail: akivrak@yyu.edu.tr

Abstract: Pd-catalyzed coupling reactions like the Sonogashira coupling reaction are very useful tools for the formation of new carbon–carbon bonds under mild reaction conditions. Coupling reactions are also used for elaboration of organic compounds in drug and material discovery. Terminal alkynes have a very critical role in Sonogashira coupling reaction. Therefore, design and synthesis of new terminal alkynes are very important for the preparation of organic compounds. In the present study, a novel alkyne 3-ethynyl-2-(thiophen-2-yl)benzo[b]thiophene 13 was synthesized, and it was tested for Sonogashira coupling reaction with different iodoaryl compounds. It was investigated whether our terminal alkyne 13 having a special construction might be a useful precursor for the synthesis of potentially active organic molecules.

Keywords: Alkynes ; Benzothiophenes ; Sonogashira coupling reaction ; C–C bond formation reactions 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-018-0640-2

Chemical Papers 73 (4) 977–985 (2019)