ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Polarographic study of 3,5-dioxopyrazolidines

L. Molnár, B. Proksa, and H. Szőcsová

Institute oj Experimental Pharmacology, Slovak Academy of Sciences, 881 05 Bratislava

Abstract: The polarog. properties of 3,5-dioxopyrazolidines (ketazon, fenylbutazon, trimetazon) studied by means of a.c. and sq. wave techniques are described. At the frequency of 120 c.p.s. the relationship between the height of double waves and pH was investigated. The change in the ratio of the heights of double waves is a function of pH and is explained by the dissocn. of the enol form of the investigated substances. The concn. dependence is of exponential character. The wave height decreases with temp. and the wave disappears in nonaq. medium. This indicates that the waves under investigation are adsorption waves.

Full paper in Portable Document Format: 283a366.pdf

Chemical Papers 28 (3) 366–369 (1974)