ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

The effect of wetting agents on the production of penicillin V

J. Fuska and H. Hronská

„Biotika", Slovenská Ľupča

Abstract: The effect of 9 wetting agents (I) on the production of penicillin V by Penicillium chrysogenum, under lab. conditions was studied. I can be divided into 3 groups according to the effects observed. The 1st group, sulfonated Bu oleate (Synferol AH), Na dibutylnaphthalenesulfonate (Neokal PR), sulfonated soybean oil (Sulfosol), and Na salts in H₂O-sol. sulfonic acids (Dubosol E) had a stimulating effect on the production of penicillin V. The 2nd group, condensation product of amino derivs, of alk. hydrolysis of protein and fatty acids (Retardon A), cetyl sulfate (Syntapon CP), and Na hexadecanesulfonate (Tergitol) had no effect. The 3rd group, a condensate of ethylene oxide with oleyl alc. (Slovasol O) and sulfonated ricinolein (Sulfopol SE 80) had an inhibitory effect.

Full paper in Portable Document Format: 173a170.pdf (in Slovak)

Chemical Papers 17 (3) 170–176 (1963)