ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Exploring synthetic xanthone derivatives as potential anti-inflammatory agents: a comprehensive review

Lokman Ali Ahmed, Babita Deka, Hiyashree Sharmah, Pooja Patowary, Deepsikha Bharali, Bhargab Jyoti Sahariah, and Apurba Talukdar

NETES Institute of Pharmaceutical Science, Private Pharmacy College, Guwahati, India

E-mail: babita.deka01@gmail.com

Received: 4 December 2023  Accepted: 18 July 2024

Abstract:

In recent years, the exploration of natural compounds for their therapeutic potential has gained considerable attention, with xanthones emerging as promising candidates due to their diverse biological activities including anti-inflammatory properties. This comprehensive review delves into the synthesis and evaluation of synthetic xanthone derivatives as potential anti-inflammatory agents. The review commences by introducing the structural characteristics and chemical diversity of synthetic xanthone derivatives, highlighting the various methods used to synthesize them. It then delves into the mechanisms underlying the anti-inflammatory effects of synthetic xanthone derivatives, focusing on their interactions with key pathways involved in inflammation. Furthermore, the review explores the relationships between the structure of synthetic xanthones and their anti-inflammatory potential, shedding light on critical structural elements responsible for their efficacy. In summary, this review consolidates our existing knowledge about synthetic xanthone derivatives as a class of compounds with remarkable anti-inflammatory properties. It underscores the importance of further research to fully understand how they work, improve their pharmacological properties, and assess their clinical benefits. Synthetic xanthone derivatives show immense promise in the search for new anti-inflammatory therapeutics, making them a compelling subject for future drug development endeavors.

Graphical abstract

Keywords: Synthetic; Xanthone; Xanthone derivatives; Anti-inflammatory

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03614-z

Chemical Papers 78 (13) 7313–7333 (2024)