ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Application of metal–organic frameworks in novel sample pretreatment techniques for occupational exposure biomonitoring: a review

Samaneh Salari, Fatemeh Dehghani, Elnaz Taheri, and Seyed Jamaleddin Shahtaheri

Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

E-mail: shahtaheri@tums.ac.ir

Received: 3 April 2023  Accepted: 7 August 2023

Abstract:

The declining trend in occupational exposure levels aimed to biomonitoring highlighted issues regarding sensitivity of analytical method and prompted the research to the development of novel pretreatment technique with strong selectivity and high recoveries. Among different functionalized sorbents, metal–organic frameworks (MOFs) with special capabilities have recently gained wide attention in biomarkers pretreatment of complicated matrices. Objective of this study was to perform a review of the publications related to MOFs derived sorbent coupled to sample pretreatment technique toward determination of biomarkers. To achieve this purpose, the PubMed, Web of Science, and Scopus databases, as well as the first 20 pages of Google Scholar, without any limitation, were searched to cover all related articles published from the beginning to March 22, 2023. Documents were found 571 results and screened for eligibility was 28 results. Finally, considering, nine publications were included in the study based on study eligibility criteria. Inclusion manuscripts in this study were published between 2014 and 2023. In this review, applications of MOF-derived sorbents combined with sample pretreatment were summarized for the determination of different biomarkers toward occupational biomonitoring that generally have only been developed for lead (from heavy metals), Benzene, Toluene, Tthylbenzene, and Xylene isomers (BTEXs) and some of their metabolites, four halogenated hydrocarbons (from Volatile Organic Compounds (VOCs)) and six organophosphorus compounds (from pesticides). MOFs can be used as high-efficiency sorbents in sample pretreatment approaches for biological matrices prior to analysis because of their exceptional and promising properties. Various novel pretreatment/preconcentration techniques along with their limitations in the application of MOFs are highlighted in this study. Moreover, the challenges, future perspectives, and trends in this field have been discussed.

Keywords: Metal–organic frameworks (MOFs); Occupational exposure; Sample preparation; Biomonitoring

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-03031-8

Chemical Papers 77 (12) 7865–7879 (2023)