ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, characterization and evaluation of the simple benzaldoximes protective effect against lipid peroxidation

Jelena Lazarević, Katarina Ilić, Jelena Zvezdanović, and Gordana Stojanović

Department of Chemistry, Faculty of Medicine, University of Niš, Niš, Serbia

E-mail: jelena217@yahoo.com

Received: 6 June 2023  Accepted: 13 September 2023

Abstract:

A series of fourteen benzaldoximes were synthetized and evaluated for antioxidant activity using lipid peroxidation (LP) method based on TBA-MDA assay, selecting BHA, BHT, troxol and quercetin as positive controls. Except for compounds 5, 6 and 9, most of the tested compounds had antioxidant properties. Compounds 12 (IC₅₀ = 25.7 ± 5.2 μM) and 13 (IC₅₀ = 55.3 ± 21.1 μM) expressed excellent antioxidant activity, having results comparable to Trolox (IC₅₀ = 22.0 ± 6.0 μM) and quercetin (IC₅₀ = 23.0 ± 6.0 μM). The results of our study on benzaldoximes might constitute a sort of a promising starting point for the development of new LP inhibitors useful for the prevention of oxidative damage.

Graphical Abstract

Keywords: Benzaldoximes; Synthesis; Antioxidant activity; Lipid peroxidation inhibition

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-03090-x

Chemical Papers 78 (1) 331–341 (2024)