ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Ti-WO₃ nanoparticle as an efficient photocatalyst in the synthesis of substituted benzimidazoles as effective glioma drugs

Ye Li, Jianjun Zhu, Nan Zhao, Gang Ma, Bohu Liu, Jiajun Xu, and Reza Tayebee

Oncology department, Kunming Children’s Hospital, Kunming, China

E-mail: jiajun.xu222@gmail.com

Received: 13 July 2023  Accepted: 7 November 2023

Abstract:

Benzimidazoles are potential compounds in the development of various important drugs and their anti-cancer properties against cancerous glioma cells. In this study, an efficient and environmental friendly photocatalyst is proposed for the synthesis of a range of 2-substituted benzimidazoles through condensation of aromatic aldehydes with o-phenylenediamine by the mediation of Ti-WO₃ nanophotocatalyst under irradiation of a commercial green laser. To characterize Ti-WO₃ several techniques such as FT-IR, DRS, XRD, XPS, TEM, and FE-SEM are employed to elucidate the structure and physicochemical properties of this nanomaterial. In addition, the reusability test confirmed excellent recovery and reproducibility of the nanophotocatalyst. Furthermore, an in-vitro cellular toxicity was performed by using Ti-WO₃ nanoparticles against the U87MG human glioma cancer cell line through MTT assay. The results showed a clear reduction in cell viability, which confirmed the cytotoxicity of Ti-WO₃ against the performed cell line.

Keywords: Photocatalysis; Aromatic aldehydes; Benzimidazoles; Glioma cancer; U87MG

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-023-03235-y

Chemical Papers 78 (4) 2263–2273 (2024)