ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Coumarin hybrids: a sighting of their roles in drug targeting

Nameer Mazin Zeki and Yasser Fakri Mustafa

Department of Pharmacology, College of Medicine, Ninevah University, Mosul, Iraq

E-mail: Dr.yassermustafa@uomosul.edu.iq

Received: 5 August 2023  Accepted: 1 May 2024

Abstract:

Phytocoumarins exhibit a range of biological activities, including antibacterial, anti-inflammatory, antiradical, oncolytic, and reduction of monoamine oxidase B effects. These compounds are frequently used by researchers to develop novel, entirely or partially laboratory-made pharmaceutical medicines derived from coumarin. Several of these medications are hybrid chemicals with different pharmacological effects that were purposefully created by applying the molecular hybridization concept. The combinations of compounds exhibit multifunctional characteristics, making them attractive options for developing therapies against complex diseases like cancer, Alzheimer’s disease, dysmetabolic syndrome, AIDS, plasmodium infection, and cardiovascular disorders. This study summarizes findings on the development of various coumarin hybrids, groups them based on prospective therapeutic uses, and makes recommendations about possible structure–activity relationships. We searched a number of database servers, including PubMed, Scopus, Google Scholar, Web of Science, and others. Following a sieve, we eventually found and incorporated 45 relevant papers that were released between 2004 and the beginning of 2024. In order to help medicinal chemists cure a range of human ailments, the authors set out to create and produce highly efficient, tailored coumarin hybrid molecules.

Graphical abstract

Keywords: Coumarins; Molecular hybridization; Drug targeting; Structure–activity relationship

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03498-z

Chemical Papers 78 (10) 5753–5772 (2024)