ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Relationship between physicochemical properties, lipophilicity parameters, and local anesthetic activity of dibasic esters of phenylcarbamic acid

I. Malík, E. Sedlárová, J. Csöllei, F. Andriamainty, and J. Čižmárik

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, SK-832 32 Bratislava, Czechoslovakia

E-mail: malik@fpharm.uniba.sk

Received: 11 July 2006  Revised: 29 January 2007  Accepted: 29 January 2007

Abstract: The basic physicochemical properties, lipophilicity parameters of dibasic alkyloxy-substituted phenylcarbamic acids were estimated. For the prepared set of compounds the experimentally obtained solubility, acidity, and lipophilicity parameters were correlated with those computed using various computer programs based on the associative artificial neural network and fragmental methods. The results of pharmacological evaluation were used as entry data for the complex correlations.

Keywords: phenylcarbamates - acidity - lipophilicity - local anesthesia - QSAR

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-007-0021-8

Chemical Papers 61 (3) 206–213 (2007)