ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Inhibition of Oxygen Evolution Rate in Freshwater Algae Chlorella vulgaris by Some Anilides of Substituted Pyridine-4-carboxylic Acids

K. Kráľová, M. Miletin, and M. Doležal

Institute of Chemistry, Faculty of Natural Sciences, Comenius University, SK 842 15 Bratislava

E-mail: kralova@fns.uniba.sk

Abstract: The inhibitory activity of 11 anilides of 2-alkylsulfanylpyridine-4-carboxylic acids (R = SC₃H₇, SC₅H₁₁, SCH₂C₆H₅, S-iC₄H₉; substituents in the anilide moiety: 2'-OH, T-OH, 5'-Cl, 3'-Br, 4'-Br, 3'-CF(3), 5'-CF₃) on oxygen evolution rate (OER) in freshwater algae Chlorella vulgaris has been investigated. The IC₅₀ values in the investigated set varied in the range from 47.7 μmol dm^-3 (R = SC₃H₇, Y = X² = H, X¹= 4'-Br) to 474.1 μmol dm^-3 (R = SCH₂C₆H₅, Y = 2'-OH, X¹ = X² = H). The dependence of photosynthesis-inhibiting activity upon the lipophilicity of the substituents showed a quasi-parabolic course indicating that for the OER-inhibiting activity in Chlorella vulgaris the lipophilicity of the compound is determining.

Full paper in Portable Document Format: 554a251.pdf

Chemical Papers 55 (4) 251–253 (2001)