ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis of N-Substituted 3-Aryl-4-cyanopyrrole Derivatives

B. Gotov and Š. Toma

Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, SK-8^2 15 Bratislava

Abstract: 3-Aryl-4-cyanopyrroles, where aryl is phenyl, 2,3-(difluoromethylenedioxy)phenyl, and ferrocenyl were prepared via TosMIC addition to the corresponding ethyl 3-aryl-2-cyanoacrylates. Their transformation to N-substituted pyrrole derivatives, the substituents being methoxycarbonyl, formamidomethyl, aminomethyl, and in one case isocyanomethyl, was also accomplished. Attempts at the preparation of N-formyl derivatives failed.

Full paper in Portable Document Format: 513a142.pdf

Chemical Papers 51 (3) 142–146 (1997)