ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Study of the Mixed Ligand Complexes of Cadmium(ll) with the Antidepressant Drug Imipramine and Glutamic Acid or Histidine Using Polarography

M. Khodari, M. A. Ghandour, H. Mansour, and H. S. Eldin

Department of Chemistry, Faculty of Science, Assiut University, Qena, Egypt

Abstract: The stability constants of binary and ternary complexes of Cd(ll) with glutamic acid (Glu) or histidine (His) as a primary ligand and imipramine (lmip) as a secondary one have been determined polarographically. The reduction process of both simple and mixed systems is reversible and diffusion-controlled. For the system Cd-Glu-lmip, two mixed complexes were formed: Cd(Glu)(lmip)₂ and Cd(Glu)₂(lmip) with stabilities log {β₁₂} = 11.45 and log {β₂₁} = 10.26, respectively. But the system Cd-His-lmip forms three mixed complexes, Cd(His)(lmip), Cd(His)(lmip)₂, and Cd(His)₂(lmip). The calculated stability constants of these complexes are log {β₁₁} = 7.17, log {β₁₂} = 10.39, and log{β₂₁} = 9.7, respectively.

Full paper in Portable Document Format: 491a21.pdf

Chemical Papers 49 (1) 21–23 (1995)