ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Copper(II) Complexes Containing Schiff Bases Derived from Salicylaldehyde and Esters of L-Glutamic Acid

M. Kohútová and A. Valent

Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-832 32 Bratislava

Received: 12 July 2001

Abstract: Copper(II) complexes of composition Cu(TSB)X, where TSB represents tridentate Schiff base derived from salicylaldehyde and L-glutamic acid as well as its methyl and ethyl esters, and X represents imidazole, 2-methylimidazole, 4-methylimidazole, and 2-ethylimidazole were synthesized and studied. Substances in question have been found to adopt square pyramidal arrangement of ligands, and from this point of view they could be taken as model substances simulating the role of natural metalloenzyme Cu,Zn—SOD in living systems. The complexes prepared exhibit significant efficacy against bacteria Staphylococcus aureus and possess also antiradical activity. The mutual influence of anionic (TSB) and neutral N-donor ligands (X) on their chemical and biological properties is discussed.

Full paper in Portable Document Format: 562a95.pdf

Chemical Papers 56 (2) 95–99 (2002)