ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

¹H and ¹³C nuclear-magnetic-resonance studies of interaction of 5'-AMPwith phenylcarbamate possessing local-anesthetic effect

M. Remko, T. Liptaj, J. Veselovská, and J. Čižmárik

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, CS-832 32 Bratislava

Abstract: ₁H and ¹³C NMR spectroscopy has been used to study the interaction of 5'-AM P with l-[2-(2-methoxyphenyiearbamoyloxy)ethyl]piperidinium chlo­ride, a local anaesthetic drug. In 0.1 niolal solution (p²H = 7.25) the interac­tion between 5'-AMP and l-[2-(2-methoxyphenylcarbamoyloxy)ethyl]piperidinium chloride was demonstrated by the chemical shifts changes in the interacting parts of the two substrates. These changes were interpreted in terms of a molecular complex formation between the aromatic part of local anaesthetic and the 5'-AMP.

Full paper in Portable Document Format: 415a583.pdf

Chemical Papers 41 (5) 583–592 (1987)