ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Thermal degradation of basic alkoxy carbanilates in a gas chromatograph

M. Štefek, L. Beneš, and V. Kováčik

Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, CS-842 16 Bratislava

Abstract:  Thermal degradation of two basic alkoxy carbanilates having local anaesthe­tic properties (pentacaine and heptacaine) was studied in the injector of a gas Chromatograph. Decomposition of these compounds was found to proceed via cleavage of the labile carbamate bond yielding an alkoxyphenyl isocyanate and the corresponding amino alcohol. The thermal degradation products were identified by GC—MS analysis comparing their retention times and mass spectra with those of reference compounds.

Full paper in Portable Document Format: 372a209.pdf

Chemical Papers 37 (2) 209–212 (1983)