ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Reaction gas chromatography of basic alkoxy carbanilates with trimethylanilinium hydroxide

M. Štefek, L. Beneš, and V. Kováčik

Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, CS-842 16 Bratislava

Abstract: Conditions for quantitative gas-chromatographic analysis of basic alkoxy carbanilates pentacaine and heptacaine after methylation with trimethylanilinium hydroxide were examined. The flash-heater derivatization reaction is reproducible and quantitative at 280°C. The reaction products, identified as N-methyl derivatives of the afore-mentioned carbanilates are thermally stable and their chromatographic response is linearly proportional to the increasing concentration.

Full paper in Portable Document Format: 372a213.pdf

Chemical Papers 37 (2) 213–216 (1983)