ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Nitrophenoxazines as neutralization indicators in acetone for determination of sulfonamides

V. Bekárek, H. Kalová, and Z. Stránský

Fac. Nat. Sci., Palacky Univ., Olomouc

Abstract:  Potentiometrie and visual microtitrations of 26 model sulfonamides and 5 pharmacologically significant sulfonamides were performed in anhydrous acetone by means of volumetric solution of tetrabutylammonium hydroxide. Linear dependence of the half-neutralization potentials on Hammett substitution constants of the substituents on benzene ring and on HMO electron densities in model series of sulfonamides has been found. 1-Nitrophenoxazine is a suitable indicator for the determination of sulfathiazole, sulfacetamide, sulfamethoxydiazine, sulfadimidine, and sulfamethoxypyridazine under the applied conditions.

Full paper in Portable Document Format: 312a231.pdf (in German)

Chemical Papers 31 (2) 231–236 (1977)