ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Antimycobacterial 1-Aryl-5-benzylsulfanyltetrazoles

K. Waisser, J. Adamec, J. Kuneš, and J. Kaustová

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, CZ-500 05 Hradec Králové, Czech Republic

E-mail: waisser@faf.cuni.cz

Received: 24 October 2003

Abstract: A group of twenty-two 1-Aryl-5-benzylsulfanyltetrazoles and 5-alkylsulfanyl-1-aryltetrazoles was synthesized, and was evaluated for in vitro antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. To describe the structure-antimycobacterial activity relationships the Hansch approach was used. Optimal values of logarithm of partition coefficients were 4.1-4.4 with the exception of M. avium. Benzylsulfanyl derivatives were more active than alkylsulfanyl derivatives.

Full paper in Portable Document Format: 583a214.pdf

Chemical Papers 58 (3) 214–219 (2004)