ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins

Biljana Dekić, Vidoslav Dekić, Niko Radulović, Rastko Vukićević, and Radosav Palić

Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia

E-mail: vangelis0703@yahoo.com

Received: 6 July 2009  Revised: 15 September 2009  Accepted: 21 September 2009

Abstract: A series of new coumarin derivatives has been synthesized by condensation of 4-chloro-3-nitrocoumarin and the appropriate arylamine and sulfonamide in ethyl acetate in the presence of triethylamine. The synthesized compounds were screened for their in vitro antimicrobial activity against thirteen strains of bacteria and three fungal/yeast strains using disk diffusion assays. They were shown to possess a wide range of activities from almost completely inactive compounds to medium active ones. (4-[(5-Chloropyridin-2-yl)amino]-3-nitro-2H-chromen-2-one) showed similar activity against Klebsiella pneumoniae as tetracycline.

Keywords: 4-arylamino-3-nitrocoumarins - 4-chloro-3-nitrocoumarin - NMR spectroscopy - antimicrobial activity

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-010-0004-z

Chemical Papers 64 (3) 354–359 (2010)