ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, Spectral and Toxicological Studies of Complex Zn(II) with Sulfadiazine

P. Guru, R. K. Gautam, and M. P. Goutam

Department of Chemistry, Dr. H . S. Gour University, Sagar, Madhya Pradesh, India 470001

E-mail: pranayguru@rediffmail.com

Received: 9 June 2003  Accepted: 16 June 2004

Abstract: The present paper deals with the spectral and toxicological studies of the complex Zn(II) with antibiotic drug sulfadiazine (2-(p-aminobenzenesulfonamido)pyrimidine), a general formula Zn(C₁₀H₁₀N₄O₂S) ·MoO₄· H₂O has been suggested for the complex under study. The geometries of the complexes have been proposed on the basis of magnetic moments, electronic and infrared spectral data. Thermogravimetric analyses have been carried out to determine the pattern of their decomposition. The crystal system, lattice parameters, unit cell volume, and number of molecules in it have been determined by X-ray diffraction data.
The toxicity of the synthesized complex was also studied on some internal organs of the albino rats like liver, kidney, adrenal gland, and testis.

Full paper in Portable Document Format: 585a341.pdf

Chemical Papers 58 (5) 341–347 (2004)