ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Complexes of Tetraiodofluorescein with Some Transition Metals and their Antitumour Activity

J. Q. Qu and L. F. Wang

National Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China

E-mail: qujq@netease.com

Received: 16 November 2000

Abstract: Cobalt(II), nickel(II), copper(II), and zinc(II) complexes of tetraiodofluorescein (H₂L) have been prepared and characterized by means of elemental analysis, molar conductivity, TG-DTA, IR, UV VIS, and 1H NMR spectra. The general formula for the complexes is ML· nH₂O where L = tetraiodofluorescein (2,7-OH group deprotonated and the lactonic ring opened); M = Zn, Cu, Co, and Ni; n = 0, 4, 5, and 2. H₂L and its complexes have been studied for their possible antitumour activity against Hep-2 pharynx cancer cells in vitro.

Full paper in Portable Document Format: 562a109.pdf

Chemical Papers 56 (2) 109–112 (2002)